Tennessee’s Bureau of Investigation (TBI) forensic drug chemistry unit confirmed its first case with nitazenes in late 2019. From January 2021 to December 2023 the forensic drug chemistry unit reported 344 cases positive for nitazenes. 227 of these cases (66%) reported one or more additional drugs in the sample, fentanyl and heroin were the most…
The presence of xylazine continues to be on the rise in samples containing fentanyl or fentanyl-related substances. A recent method published in the Journal of Chromatography B uses SPE and LC/MS-MS to quantitate xylazine, 4-ANPP, acetyl fentanyl, fentanyl, norfentanyl, and p-fluorofentanyl. Xylazine is rarely abused on its own, and research suggests it has effects comparable…
The abuse of fentanyl, a synthetic opioid, is well known in humans. However, its misuse is becoming more popular in horseracing to enhance the performance of the racehorses. Fentanyl has both an analgesic and stimulatory effect on horses. The use of fentanyl in equine sports is prohibited by both the Association of Racing Commissioners International…
Fentanyl, a well-known synthetic opioid approximately 100 times more potent than morphine, continues to be a public health issue. In cases of a fentanyl overdose, it is difficult to determine the cause of death based on toxicological information alone due to the tolerance of habitual users and significant post-mortem redistribution. An Italian group published a…
Fentanyl serves as a powerful analgesic agent to manage pain during labor and delivery. However, prolonged prenatal exposure can make babies drug dependent and sudden discontinuation may result in conditions like Neonatal Abstinence Syndrome (NAS) or Neonatal Opioid Withdrawal Syndrome (NOWS). Adequate literature on the suitability of umbilical cord as a specimen for drug testing…
UCT’s famous Clean Screen® DAU was used to extract fentanyl and 18 additional compounds from whole blood samples. A fit-for-purpose method validation adapted from SWGTOX was performed by assessing the following criteria over five days: bias, precision, linear dynamic range, interferences and carryover.
One of the more recent prescription drugs being abused illicitly is Fentanyl. This compound induces pharmacological effects and abuse liability comparable to other prescription opioids and heroin. A surge in fentanyl-related fatalities has been periodically reported throughout the USA. In an article published in the Special Issue of the Journal of Analytical Toxicology (JAT) by a team lead by Prof. B. A. Goldberger ((2016) 40:588–594), UCT’s flagship sorbent Clean Screen® DAU was employed to extract and analyze post mortem blood samples for fentanyl.
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