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Incorporation of Clean Screen FASt® extraction in the study of ZCZ-011 in mouse brain tissue helps minimize and stabilize matrix ion suppression effects
Researchers at the Virginia Commonwealth University (Richmond, VA, USA), University of Aberdeen (Aberdeen, U.K.) and the University of Toronto (Toronto, Canada) have developed a novel pharmacological tool for the investigation of the cannabinoid receptor in mouse brain tissue using HPLC-MS-MS analysis.
Top 10 Forensic Compounds/Topics of 2016 – Designer Benzodiazepine Analysis
Compared to other classes of drugs, benzodiazepine abuse is relatively uncommon. However, there has been an upward trend of using them along with other drugs, such as alcohol and opioids, in order to achieve an enhanced overall high.
UCT’s Clean Screen® Xcel 1 SPE 96 Well Plates Cited in Animal Study
The correlation of drugs in decomposed human remains and animals is very useful for forensic toxicologists working with complex matrices that go beyond post mortem samples. In a recent paper published in Journal of Analytical Toxicology, Lucas M. Morrison et al.,(doi: 10.1093/jat/bkx040) employed UCT’s famous Xcel I SPE sorbent to extract Dextromethorphan (DXM) and its primary metabolite (DXT) from the remains of rats. They analyzed DXM and DXT in skeletal remains of rats following acute (ACU, 75 mg/kg, IP, n = 10) or three repeated (REP, 25 mg/kg, IP, n = 10, 40-minute intervals) doses of DXM.
UCT Flagship Sorbent Clean Screen® DAU cited in new Fentanyl/Opioids Analogs Paper
Since the introduction of Fentanyl as a legitimate medication, UCT has been at the forefront of assisting forensic toxicology facilities with the finest solid-phase extraction (SPE) sorbents and methodologies to extract and concentrate the drugs efficiently. With the recent emergence of newer potent analogs in the illicit community, UCT has expanded upon its existing sample preparation methods to include these novel, structurally similar derivatives. In a new paper authored by E.N.Shoff et al., published in Journal of Analytical Toxicology (doi: 10.1093/jat/bkx041), the determination of fentanyl analogs and other opioids in postmortem cases is thoroughly detailed employing Clean Screen® DAU solid-phase extraction cartridges as an integral part of this methodology.
Clean Screen® DAU Columns in Zolpidem urinary metabolite detection study
An article titled, ‘Determining Zolpidem Compliance: Urinary Metabolite Detection and Prevalence in Chronic Pain Patients’ was recently published in the Journal of Analytical Toxicology (DOI: 10.1093/jat/bku068).
Endcapped C18 Helps Researchers Achieve Excellent Analyte Sensitivity and Recovery for 131 Drug Residues in Bovine Muscle
Marilyn J Schneider, Steven J Lehotay, and Alan R Lightfield at the US Department of Agriculture recently published a paper in the journal Analytical and Bioanalytical Chemistry.